Article
A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence.
Cell reports - 10 Apr 2018
de Souza Camila Ferreira, Sabedot Thais S, Malta Tathiane M, Stetson Lindsay, Morozova Olena, Sokolov Artem, Laird Peter W, Wiznerowicz Maciej, Iavarone Antonio, Snyder James, deCarvalho Ana, Sanborn Zachary, McDonald Kerrie L, Friedman William A, Tirapelli Daniela, Poisson Laila, Mikkelsen Tom, Carlotti Carlos G, Kalkanis Steven, Zenklusen Jean, Salama Sofie R, Barnholtz-Sloan Jill S, Noushmehr Houtan
Abstract excerpt
Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have developed. To date, no bona fide biomarkers that significantly translate into a survival benefit to glioblastoma patients have been identified. We previously reported that the IDH mutant G-CIMP-high subtype would be a predecessor to the G-CIMP-low subtype. Here,...
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