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Article

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.

Cancer cell - 18 May 2010

Noushmehr Houtan, Weisenberger Daniel J, Diefes Kristin, Phillips Heidi S, Pujara Kanan, Berman Benjamin P, Pan Fei, Pelloski Christopher E, Sulman Erik P, Bhat Krishna P, Verhaak Roel G W, Hoadley Katherine A, Hayes D Neil, Perou Charles M, Schmidt Heather K, Ding Li, Wilson Richard K, Van Den Berg David, Shen Hui, Bengtsson Henrik, Neuvial Pierre, Cope Leslie M, Buckley Jonathan, Herman James G, Baylin Stephen B, Laird Peter W, Aldape Kenneth

Abstract excerpt

We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted hypermethylation at a large number of loci, indicating the existence of a glioma-CpG island methylator p...

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Source

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Identifiers

PMID: 20399149
DOI: 10.1016/j.ccr.2010.03.017
PMCID: PMC2872684

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20399149-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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