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CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning.

Molecular psychiatry - 1 Sept 2025

Teter Olivia M, McQuade Amanda, Hagan Venus, Liang Weiwei, Dräger Nina M, Sattler Sydney M, Holmes Brandon B, Castillo Vincent Cele, Papakis Vasileios, Leng Kun, Boggess Steven, Nowakowski Tomasz J, Wells James, Kampmann Martin

Abstract excerpt

Autism Spectrum Disorders (ASD) are a set of neurodevelopmental disorders with complex biology. The identification of ASD risk genes from exome-wide association studies and de novo variation analyses has enabled mechanistic investigations into how ASD-risk genes alter development. Most functional genomics studies have focused on the role of these genes in neurons and neural progenitor cells. However, roles for...

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Identifiers

PMID: 40188316
DOI: 10.1038/s41380-025-02997-z
PMCID: PMC12339388

Genes

ADNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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