Article

The “don’t eat me” signal CD47 contributes to microglial phagocytosis defects and autism-like behaviors in 16p11.2 deletion mice

2024-06-08

Abstract excerpt

Various pathological characteristics of autism spectrum disorder (ASD) stem from abnormalities in brain resident immune cells, specifically microglia, to prune unnecessary synapses or neural connections during early development. Animal models of ASD exhibit an abundance of synapses in different brain regions, which is strongly linked to the appearance of ASD behaviors. Overexpression of CD47 on neurons acts as a “...

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Literature Corpus work: b50d74cd-9e85-59bf-8423-49ed551a5dd3
DOI: 10.1101/2024.06.07.597763

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