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Article

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

12 Jul 2016

Abstract excerpt

Autism spectrum disorders (ASDs) are neurodevelopmental disorders caused by various genetic and environmental factors that result in synaptic abnormalities. ASD development is suggested to involve microglia, which have a role in synaptic refinement during development. Autophagy and related pathways are also suggested to be involved in ASDs. However, the precise roles of microglial autophagy in synapses and ASDs...

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PMID: 27400854
DOI: 10.1038/mp.2016.103

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