Article

Loss of function in the autism and schizophrenia-associated gene <i>CYFIP1</i> in human microglia supports a role in synaptic pruning

2022-10-24

Abstract excerpt

<h4>Background</h4> The CYFIP1 gene, located in the neurodevelopmental risk locus 15q11.2, is highly expressed in microglia, but its role in human microglial function as it relates to neurodevelopment is not well understood. <h4>Methods</h4> We generated multiple CRISPR knockouts of CYFIP1 in patient-derived models of microglia to characterize function and phenotype. Using microglia-like cells reprogrammed fr...

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Literature Corpus work: 3fa880df-28b5-5eeb-9793-970ced5b80fb
DOI: 10.1101/2022.10.24.513576

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Loss of function in the autism and schizophrenia-associated gene <i>CYFIP1</i> in human microglia supports a role in synaptic pruningDOI 10.1101/2022.10.24.513576Read

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