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Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloids

2025-06-04

Abstract excerpt

<h4>ABSTRACT</h4> Microglia critically shape neuronal circuit development and function, yet their region-specific properties and roles in distinct circuits of the human brain remain poorly understood. In this study, we generated region-specific brain organoids (cortical, striatal, and midbrain), each integrated with human microglia, to fill this critical gap. Single-cell RNA sequencing uncovered six distinct micr...

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Literature Corpus work
85b7391e-c9aa-5c51-8ebb-e54d013ab735
DOI
10.1101/2025.06.04.657874
Open publication

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Human microglia in brain assembloids display region- specific diversity and respond to hyperexcitable neurons carrying <i>SCN2A</i> mutation: Microglial diversity and response in assembloidsDOI 10.1101/2025.06.04.657874
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