Article

Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids

2023-09-28

Abstract excerpt

<title>Abstract</title> Autism spectrum disorder (ASD) is a major neurodevelopmental disorder affecting 1 in 36 children in the United States. While neurons have been the focus to understand ASD, an altered neuro-immune response in the brain may be closely associated with ASD, and a neuro-immune interaction could play a role in the disease progression. As the resident immune cells of the brain, microglia regul...

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Literature Corpus work: 2c694ca3-4e74-589b-81e2-568199e2ed6f
DOI: 10.21203/rs.3.rs-3270664/v1

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