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Article

Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer.

Cellular and molecular life sciences : CMLS - 1 Dec 2021

Bailey Charles G, Gupta Shailendra, Metierre Cynthia, Amarasekera Punkaja M S, O'Young Patrick, Kyaw Wunna, Laletin Tatyana, Francis Habib, Semaan Crystal, Sharifi Tabar Mehdi, Singh Krishna P, Mullighan Charles G, Wolkenhauer Olaf, Schmitz Ulf, Rasko John E J

Abstract excerpt

CCCTC-binding factor (CTCF) plays fundamental roles in transcriptional regulation and chromatin architecture maintenance. CTCF is also a tumour suppressor frequently mutated in cancer, however, the structural and functional impact of mutations have not been examined. We performed molecular and structural characterisation of five cancer-specific CTCF missense zinc finger (ZF) mutations occurring within key intra-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34657170
DOI: 10.1007/s00018-021-03946-z
PMCID: PMC8629902

Genes

CTCF

Variants

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