Article
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.
PLoS genetics - 1 Nov 2014
Ding Zhihao, Ni Yunyun, Timmer Sander W, Lee Bum-Kyu, Battenhouse Anna, Louzada Sandra, Yang Fengtang, Dunham Ian, Crawford Gregory E, Lieb Jason D, Durbin Richard, Iyer Vishwanath R, Birney Ewan
Abstract excerpt
Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding of a transcription factor in humans, we measured binding of the multifunctional transcription and chromatin factor CTCF in 51 HapMap cell lines. We identified thousands of QTLs in which...
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