Article

DNA sequence quantitatively encodes CTCF-binding affinity at genome scale

2026-01-05

Abstract excerpt

CTCF is a central architectural protein that shapes 3D genome organization through sequence-specific DNA binding, but how DNA sequence quantitatively determines CTCF-binding strength remains poorly understood. Progress has been hampered by the lack of large, high-quality measurements of binding affinity. Here, we experimentally determine in vitro CTCF-binding affinity for 276,765 DNA sequences derived from the hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b089a142-f64b-5f5b-82fd-d2030c5032ae
DOI: 10.64898/2026.01.05.696797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA sequence quantitatively encodes CTCF-binding affinity at genome scaleDOI 10.64898/2026.01.05.696797Read

Inferring CTCF binding patterns and anchored loops across human tissues and cell typesSemantic proximity Read

AlphaGenome: advancing regulatory variant effect prediction with a unified DNA sequence modelSemantic proximity Read

Identifying deleterious noncoding variation through gain and loss of CTCF binding activity.Semantic proximity Read

ChromBPNet: bias factorized, base-resolution deep learning models of chromatin accessibility reveal cis-regulatory sequence syntax, transcription factor footprints and regulatory variantsSemantic proximity Read

Advancing regulatory variant effect prediction with AlphaGenome.Semantic proximity Read

Prediction of Transcription Factor DNA Binding Affinity with High-Throughput <i>K</i> <sub>d</sub> Measurements and Deep LearningSemantic proximity Read

Advancing Transcription Factor Binding Site Prediction Using DNA Breathing Dynamics and Sequence Transformers via Cross AttentionSemantic proximity Read

A deep learning approach to predict the impact of non-coding sequence variants on 3D chromatin structureSemantic proximity Read

Effective gene expression prediction from sequence by integrating long-range interactionsSemantic proximity Read

Deep neural networks identify context-specific determinants of transcription factor binding affinitySemantic proximity Read

Deep learning framework ChIANet predicts protein-mediated chromatin architecture across functional contextsSemantic proximity Read

Ultra-fast variant effect prediction using biophysical transcription factor binding modelsSemantic proximity Read