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Article

Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites.

Nucleic acids research - 12 Aug 2024

Chen Wenhan, Zeng Yi C, Achinger-Kawecka Joanna, Campbell Elyssa, Jones Alicia K, Stewart Alastair G, Khoury Amanda, Clark Susan J

Abstract excerpt

CCCTC-binding factor (CTCF) is an insulator protein that binds to a highly conserved DNA motif and facilitates regulation of three-dimensional (3D) nuclear architecture and transcription. CTCF binding sites (CTCF-BSs) reside in non-coding DNA and are frequently mutated in cancer. Our previous study identified a small subclass of CTCF-BSs that are resistant to CTCF knock down, termed persistent CTCF binding sites...

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Identifiers

PMID: 38950902
DOI: 10.1093/nar/gkae530
PMCID: PMC11317138

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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