Article

Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity

2026-04-18

Abstract excerpt

Genotoxic cancer therapies introduce DNA damage that can be fixed as somatic mutations in surviving tumor cells. However, the impact of therapy-associated mutagenesis on regulatory elements remains unclear. CTCF binding sites (CBS) are chromatin architectural elements that exhibit recurrent localized mutation enrichment in cancer genomes. We asked whether treatment exposure is associated with increased mutagenesis...

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Literature Corpus work: cbe2affc-3231-594e-a748-66434e594aaa
DOI: 10.64898/2026.04.15.718780

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