Article

Genome-wide meta-analysis, fine-mapping, and integrative prioritization identify new Alzheimer’s disease risk genes

2020-01-27

Abstract excerpt

Genome-wide association studies (GWAS) have discovered numerous genomic loci associated with Alzheimer’s disease (AD), yet the causal genes and variants remain incompletely identified. We performed an updated genome-wide AD meta-analysis, which identified 37 risk loci, including novel associations near genes CCDC6, TSPAN14, NCK2 , and SPRED2 . Using three SNP-level fine-mapping methods, we identified 21 SNPs with...

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Literature Corpus work: dad5be8f-f4cd-5c4b-838f-c81d63c7774b
DOI: 10.1101/2020.01.22.20018424

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