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Article

Polygenic Scores of Cardiometabolic Risk Factors in American Indian Adults.

JAMA network open - 3 Mar 2025

Sun Quan, Du Jiawen, Tang Yihan, Best Lyle G, Haack Karin, Zhang Ying, Cole Shelley A, Franceschini Nora

Abstract excerpt

Importance: Numerous efforts have been made to include diverse populations in genetic studies, but American Indian populations are still severely underrepresented. Polygenic scores derived from genetic data have been proposed in clinical care, but how polygenic scores perform in American Indian individuals and whether they can predict disease risk in this population remains unknown. Objective: To study the...

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PMID: 40072435
DOI: 10.1001/jamanetworkopen.2025.0535
PMCID: PMC11904716

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