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Article

Influence and role of polygenic risk score in the development of 32 complex diseases

10 Mar 2025

Abstract excerpt

Background: The polygenic risk score (PRS) has been perceived as advantageous in predicting the risk of complex diseases compared to other measures. We aimed to systematically evaluate the influence of PRS on disease outcome and to explore its predictive value. Methods: We comprehensively assessed the relationship between PRS and 32 complex diseases in the UK Biobank. We used Cox models to estimate the effects of...

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PMID: 40063714
DOI: 10.7189/jogh.15.04071

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