Article
A perspective on genetic and polygenic risk scores-advances and limitations and overview of associated tools.
Briefings in bioinformatics - 27 Mar 2024
Schwarzerova Jana, Hurta Martin, Barton Vojtech, Lexa Matej, Walther Dirk, Provaznik Valentine, Weckwerth Wolfram
Abstract excerpt
Polygenetic Risk Scores are used to evaluate an individual's vulnerability to developing specific diseases or conditions based on their genetic composition, by taking into account numerous genetic variations. This article provides an overview of the concept of Polygenic Risk Scores (PRS). We elucidate the historical advancements of PRS, their advantages and shortcomings in comparison with other predictive...
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