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Article

From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.

JAMA psychiatry - 1 Jan 2021

Wray Naomi R, Lin Tian, Austin Jehannine, McGrath John J, Hickie Ian B, Murray Graham K, Visscher Peter M

Abstract excerpt

Importance: Polygenic risk scores (PRS) are predictors of the genetic susceptibilities of individuals to diseases. All individuals have DNA risk variants for all common diseases, but genetic susceptibility differences between people reflect the cumulative burden of these. Polygenic risk scores for an individual are calculated as weighted counts of thousands of risk variants that they carry, where the risk...

Topics

Biomedical Research
Clinical Decision-Making
Diagnosis
Genetic Predisposition to Disease
Humans
Multifactorial Inheritance

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32997097
DOI: 10.1001/jamapsychiatry.2020.3049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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