Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical utility of polygenic risk scores: a critical 2023 appraisal

3 May 2023

Abstract excerpt

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009, polygenic risk scores (PRSs) have been described for a large number of common complex diseases. However, the clinical utility of PRSs in disease risk assessment or therapeutic decision making is likely limited because PRSs usually only account for the heritable component of a trait and ignore the etiological role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Genetic factors in colorectal cancer

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37133683
DOI: 10.1007/s12687-023-00645-z

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical utility of polygenic risk scores: a critical 2023 appraisalPMID 37133683Read ↗

A systematic framework for assessing the clinical impact of polygenic risk scoresSemantic proximity Read ↗

Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score CatalogSemantic proximity Read ↗

Polygenic Risk Scores in Human Disease.Semantic proximity Read ↗

Clinical use of polygenic risk scores: current status, barriers and future directions.Semantic proximity Read ↗

Could Polygenic Risk Scores Be Useful in Psychiatry?: A Review.Semantic proximity Read ↗

Polygenic risk scores: from research tools to clinical instruments.Semantic proximity Read ↗

From Basic Science to Clinical Application of Polygenic Risk Scores: A Primer.Semantic proximity Read ↗

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.Semantic proximity Read ↗

A perspective on genetic and polygenic risk scores-advances and limitations and overview of associated tools.Semantic proximity Read ↗

Identifying and characterizing disease subpopulations that most benefit from polygenic risk scores.Semantic proximity Read ↗

Utility of polygenic scores across diverse diseases in a hospital cohort for predictive modeling.Semantic proximity Read ↗

Exploring the predictive power of polygenic scores derived from genome-wide association studies: a study of 10 complex traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.