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ETVs dictate hPSC differentiation by tuning biophysical properties

26 Feb 2025

Abstract excerpt

Stem cells maintain a dynamic dialog with their niche, integrating biochemical and biophysical cues to modulate cellular behavior. Yet, the transcriptional networks that regulate cellular biophysical properties remain poorly defined. Here, we leverage human pluripotent stem cells (hPSCs) and two morphogenesis models - gastruloids and pancreatic differentiation - to establish ETV transcription factors as critical...

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PMID: 40011454
DOI: 10.1038/s41467-025-56591-6

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