Article

Mechanics regulate human embryonic stem cell self-organization to specify mesoderm

2020-02-11

Abstract excerpt

Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level force. Whether cell tension regulates development by directly influencing morphogen signaling remains unclear. Human embryonic stem cells (hESCs) exhibit an intrinsic capacit...

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Literature Corpus work: 3d595a5b-d92b-54fd-8137-e2ef5d7917ba
DOI: 10.1101/2020.02.10.943076

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