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Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation

2025-05-20

Abstract excerpt

Spina bifida and anencephaly are neural tube defects caused by failure of embryonic neural tube closure. Successful closure requires apicobasal elongation and apical constriction of neuroepithelial cells. These critical behaviours have not been studied in human, patient-specific models. We characterise a human iPSC-derived neuroepithelial morphogenesis model that is highly reproducible across three parental iPSC l...

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Literature Corpus work
a2bc5e84-8d5f-5abc-a1cb-5495b3cc2100
DOI
10.1101/2025.05.16.654453
Open publication

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Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiationDOI 10.1101/2025.05.16.654453
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