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Article

Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy

17 Aug 2023

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-threatening arrhythmias and myocardial dysfunction. Pathogenic variants in Plakophilin-2 ( PKP2 ), a desmosome component within specialized cardiac cell junctions, cause the majority of ACM cases. However, the molecular mechanisms by which PKP2 variants induce disease phenotypes remain unclear. Here we built bioengineered...

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PMID: 37595583
DOI: 10.1016/j.stemcr.2023.07.005

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