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Article

Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR mice.

Biology of sex differences - 20 Jan 2025

Lin Yingbin, Luo Xinqun, Wang Fangyu, Cai Huange, Lin Yuanxiang, Kang Dezhi, Fang Wenhua

Abstract excerpt

BACKGROUND: Apolipoprotein E4 (ApoE4) is associated with an increased risk of Alzheimer's disease (AD), depression, and anxiety, which were reported to improve after the administration of metformin. However, sex influence on the effect of ApoE4 and metformin on cognition and mental health is poorly understood. METHODS: ApoE3-TR and apoE4-TR mice of both sexes were randomly assigned to the normal saline and...

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Identifiers

PMID: 39833961
DOI: 10.1186/s13293-025-00684-w
PMCID: PMC11744935

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