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Article

Early-life stress leads to impaired spatial learning and memory in middle-aged ApoE4-TR mice

12 Jul 2016

Abstract excerpt

BACKGROUND: Apolipoprotein E (ApoE) is a major lipid carrier that supports lipid transport and injury repair in the brain. The APOE ε4 allele is associated with depression, mild cognitive impairment (MCI) and dementia; however, the precise molecular mechanism through which ApoE4 influences the risk of disease development remains unknown. To address this gap in knowledge, we investigated the potential effects of...

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PMID: 27406263
DOI: 10.1186/s13024-016-0107-2

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