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Metformin treatment improves the spatial memory of aged mice in an APOE genotype–dependent manner

20 Mar 2019

Abstract excerpt

ABSTRACT Aging and apolipoprotein E4 (ApoE4) can increase the risk of cognitive impairment and neurodegenerative disorders, including Alzheimer's disease (AD), and patients with type 2 diabetes mellitus are highly susceptible to cognitive dysfunction. Recent research has indicated that metformin, a prescribed drug for type 2 diabetes, may affect cognitive function; however, findings regarding its efficacy are...

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PMID: 30894020
DOI: 10.1096/fj.201802718r

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