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Article

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.

PloS one - 1 Jan 2016

Lane-Donovan Courtney, Herz Joachim

Abstract excerpt

Alzheimer's disease is a currently incurable neurodegenerative disease affecting millions of individuals worldwide. Risk factors for Alzheimer's disease include genetic risk factors, such as possession of ε4 allele of apolipoprotein E (ApoE4) over the risk-neutral ApoE3 allele, and lifestyle risk factors, such as diet and exercise. The intersection of these two sources of disease risk is not well understood. We...

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Apolipoprotein E3
Apolipoprotein E4
Carbohydrates
Diet, High-Fat
Diet, Ketogenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

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PMID: 26828652
DOI: 10.1371/journal.pone.0148099
PMCID: PMC4734705

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