Article
APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline.
Translational psychiatry - 5 Oct 2021
Fang Wenting, Xiao Naian, Zeng Guirong, Bi Daode, Dai Xiaoman, Mi Xue, Ye Qinyong, Chen Xiaochun, Zhang Jing
Abstract excerpt
Population-based studies reveal that apolipoprotein E (APOE) ε4 gene allele is closely associated with late-life depression (LLD). However, its exact role and underlying mechanism remain obscure. The current study found that aged apoE4-targeted replacement (TR) mice displayed obvious depression-like behavior when compared with age-matched apoE3-TR mice. Furthermore, apoE4 increased stress-induced depression-like...
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