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Metabolic Disturbances of a High-Fat Diet Are Dependent on APOE Genotype and Sex

1 Sept 2019

Abstract excerpt

Abstract Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer’s disease (AD).APOE4is also associated with an increased risk of metabolic syndrome. Obesity is a major environmental risk factor for AD. WhileAPOEgenotype and obesity independently affect metabolism and cognition, they may also have synergistic effects. Here, we examined the metabolic and behavioral alterations associated with...

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PMID: 31554665
DOI: 10.1523/eneuro.0267-19.2019

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