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Article

Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice.

Neurobiology of aging - 1 Feb 2012

Siegel Jessica A, Haley Gwendolen E, Raber Jacob

Abstract excerpt

Compared with apoE3, apoE4 is associated with increased risk to develop age-related cognitive decline, particularly in women. In this study, young, middle-aged, and old female mice expressing human apoE under control of the mouse apoE promoter were behaviorally analyzed. Cognitive performance in the water maze decreased with age in all mice. Compared with apoE2 and apoE3 mice, apoE4 mice showed better cognitive...

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Source

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Identifiers

PMID: 20400205
DOI: 10.1016/j.neurobiolaging.2010.03.002
PMCID: PMC2935518

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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