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Article

Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2025

Jiang Hui, Zhao Yaping, Jin Mei, Zhang Zhidan, Wang Li, Cheng Xiang, Huang Yu, Liu Zhiping, Weng Jianping, Xu Suowen

Abstract excerpt

BACKGROUND: Aortic dissection (AD) is a severe cardiovascular disorder characterized by intimal tearing and subsequent delamination of the aortic wall. The pathogenesis of AD primarily involves the phenotypic switch of vascular smooth muscle cells (VSMCs), degradation of the extracellular matrix, and chronic vascular inflammation. Colchicine, an alkaloid derived from Colchicum autumnale L, is a Food and Drug...

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PMID: 40177774
DOI: 10.1161/ATVBAHA.124.322252

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