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Article

Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells.

Journal of molecular and cellular cardiology - 1 Jun 2026

Li Dongxu, Li Li, Fan Yingying, Lu Caiyun, Feng Nan, Zhang Chaowei, Gao Ji, Sun Siyu, Wang Xiulong, Li Xuefang, Wang Libo, Chen Zhigang, Zhao Guoan, Lin Fei

Abstract excerpt

Neointimal hyperplasia results from irregular vascular smooth muscle cell (VSMC) proliferation and migration. Lycorine hydrochloride (LH), known for its cardioprotective properties, was investigated for its impact on neointimal hyperplasia and underlying mechanisms. In a murine model of left common carotid artery ligation (CAL)-induced neointimal hyperplasia, LH was administered intraperitoneally for 28 days....

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Identifiers

PMID: 42061807
DOI: 10.1016/j.yjmcc.2026.04.008

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