Article

Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

2023-08-06

Abstract excerpt

Smoking, alcohol abuse, and hypertension are – among others the potential risk factors for cardiovascular diseases. These risk factors generate oxidative stress and cause oxidative stress-induced DNA damage, resulting in cellular senescence and senescence-associated secretory phenotype (SASP). The SASP factors in feed-forward response exacerbate inflammation and cause tissue remodeling, resulting in atheroscleroti...

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Literature Corpus work: d50a3a3c-5752-55ea-b9af-d784f6db2b50
DOI: 10.1101/2023.08.04.552075

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