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Article

Effect of sinomenine on vascular smooth muscle cell dedifferentiation and neointima formation after vascular injury in mice.

Molecular and cellular biochemistry - 1 Jan 2013

Zhu Lihua, Hao Yarong, Guan Hongjing, Cui Changping, Tian Song, Yang Da, Wang Xinan, Zhang Shuming, Wang Lang, Jiang Hong

Abstract excerpt

Sinomenine, a pure alkaloid extract from Sinomenium acutum, has anti-inflammatory and immunoregulatory functions. This study investigated the efficiency and the signalling pathways involved in the effect of sinomenine on vascular smooth muscle cell (VSMC) dedifferentiation in response to platelet-derived growth factor (PDGF)-BB stimulation and vascular injury. VSMCs were isolated from rat aorta and preincubated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Muscle, Smooth, Vascular

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Share to Receptors, Platelet-Derived Growth Factor

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Source

Identifiers

PMID: 23065380
DOI: 10.1007/s11010-012-1474-9

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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