The novel piperlongumine-ligustrazine derivative PL-Lig-11 inhibits VSMC phenotypic switching and intimal hyperplasia via the PDGFRα/β-RhoGDI3-NLRP3 inflammasome axis.

Abstract excerpt

Neointimal hyperplasia driven by vascular smooth muscle cell (VSMC) phenotypic switching is a key pathological process in cardiovascular diseases. This study investigated the effects and mechanisms of PL-Lig-11, a novel derivative combining piperlongumine (PL) and ligustrazine (Lig), on VSMC phenotypic switching and intimal hyperplasia. PL-Lig-11 significantly suppressed PDGF-BB-induced VSMC proliferation,...

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