Article
Atorvastatin regulates vascular smooth muscle cell phenotypic transformation by epigenetically modulating contractile proteins and mediating Akt/FOXO4 axis.
Molecular medicine reports - 1 May 2022
Du Xinping, Sun Zhiyuan, Cao Zhongnan, Zhou Xiuhong, Wang Dong, Wang Kuan, Li Xuebin, Zuo Guoxing
Abstract excerpt
Atherosclerosis (AS) is a prevalent cardiovascular disease with severe morbidity and high mortality. Phenotypic regulation of vascular smooth muscle cells (VSMCs) from the contractile and quiescent phenotype to the synthetic type is a critical step for the vascular remodeling of AS. Atorvastatin, as a 3‑hydroxy‑3‑methyl‑glutaryl coenzyme A reductase inhibitor, presents an anti‑inflammatory effect to improve...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.