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Oroxylin A Suppresses Pathological Vascular Smooth Muscle Cell Phenotypic Switching and Neointima Formation Through Hindering TSC2/mTORC1/HIF-1-Dependent Glycolysis.

Phytotherapy research : PTR - 1 Mar 2026

Cao Kaixiang, Song Mingchuan, Yu Runfa, Zhao Yuan, Chen Peiling, Wang Cailing, Guo Shuai, Li Ziling, Li Yanling, Dang Yuanye, He Jun, Xu Yiming

Abstract excerpt

Neointima formation, characterized by similarities to tumor-like growth, plays a pivotal role in the progression of vascular occlusive diseases. Oroxylin A (OroA), a bioactive flavonoid from Scutellaria roots, shows protective effects against cardiovascular diseases and cancers. This study explores whether OroA inhibits neointima formation caused by vascular injury and investigates the mechanisms involved. Models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mechanistic Target of Rapamycin Complex 1

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

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Share to Tuberous Sclerosis Complex 2 Protein

Source

Identifiers

PMID: 41520366
DOI: 10.1002/ptr.70145

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Oroxylin A Suppresses Pathological Vascular Smooth Muscle Cell Phenotypic Switching and Neointima Formation Through Hindering TSC2/mTORC1/HIF-1-Dependent Glycolysis.PMID 41520366Read ↗

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