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Article

Tanshinone II A attenuates vascular remodeling through klf4 mediated smooth muscle cell phenotypic switching.

Scientific reports - 17 Aug 2020

Lou Guanhua, Hu Wangming, Wu Ziqiang, Xu Huan, Yao Huan, Wang Yang, Huang Qinwan, Wang Baojia, Wen Li, Gong Daoying, Chen Xiongbing, Shi Yaping, Yang Lan, Xu Yiming, Wang Yong

Abstract excerpt

The aim of this study is to investigate the therapeutic role of Tanshinone II A, a key integrant from salvia miltiorrhiza, against pathological vascular remodeling. Completed ligation of mouse left common carotid arteries animal model and rat smooth muscle cells used to investigate the role of Tanshinone II A in regulating pathological vascular remodeling through hematoxylin and eosin staining,...

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Identifiers

PMID: 32807822
DOI: 10.1038/s41598-020-70887-1
PMCID: PMC7431534

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