Article
Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.
Nature genetics - 1 Jan 2017
Dunford Andrew, Weinstock David M, Savova Virginia, Schumacher Steven E, Cleary John P, Yoda Akinori, Sullivan Timothy J, Hess Julian M, Gimelbrant Alexander A, Beroukhim Rameen, Lawrence Michael S, Getz Gad, Lane Andrew A
Abstract excerpt
There is a striking and unexplained male predominance across many cancer types. A subset of X-chromosome genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative 'escape from X-inactivation tumor-suppressor' (EXITS) genes, we examined somatic alterations from >4,100 cancers across 21 tumor types for sex bias. Six of 783...
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