Article
Paternally biased X inactivation in mouse neonatal brain.
Genome biology - 1 Jan 2010
Wang Xu, Soloway Paul D, Clark Andrew G
Abstract excerpt
BACKGROUND: X inactivation in female eutherian mammals has long been considered to occur at random in embryonic and postnatal tissues. Methods for scoring allele-specific differential expression with a high degree of accuracy have recently motivated a quantitative reassessment of the randomness of X inactivation. RESULTS: After RNA-seq data revealed what appeared to be a chromosome-wide bias toward...
Topics
- Alleles
- Analysis of Variance
- Animals
- Animals, Newborn
- Brain
- Chromosomes, Mammalian
- Cluster Analysis
- Crosses, Genetic
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Genomic Imprinting
- Least-Squares Analysis
- Male
- Mice
- Regulatory Sequences, Nucleic Acid
- Selection Bias
- Statistics, Nonparametric