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Article

Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach.

Genome biology - 16 Apr 2021

Genolet Oriana, Monaco Anna A, Dunkel Ilona, Boettcher Michael, Schulz Edda G

Abstract excerpt

BACKGROUND: X-chromosomal genes contribute to sex differences, in particular during early development, when both X chromosomes are active in females. Double X-dosage shifts female pluripotent cells towards the naive stem cell state by increasing pluripotency factor expression, inhibiting the differentiation-promoting MAP kinase (MAPK) signaling pathway, and delaying differentiation. RESULTS: To identify the...

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Source

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Identifiers

PMID: 33863351
DOI: 10.1186/s13059-021-02321-2
PMCID: PMC8051100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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