Article
A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation.
Nucleic acids research - 11 Dec 2024
Muhammad Abubakar, Sarkadi Zsuzsa, Mazumder Agnisrota, Ait Saada Anissia, van Emden Thomas, Capella Matias, Fekete Gergely, Suma Sreechakram Vishnu N, Al-Sady Bassem, Lambert Sarah A E, Papp Balázs, Barrales Ramón Ramos, Braun Sigurd
Abstract excerpt
Heterochromatin plays a critical role in regulating gene expression and maintaining genome integrity. While structural and enzymatic components have been linked to heterochromatin establishment, a comprehensive view of the underlying pathways at diverse heterochromatin domains remains elusive. Here, we developed a systematic approach to identify factors involved in heterochromatin silencing at pericentromeres,...
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