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Article

Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe.

G3 (Bethesda, Md.) - 8 May 2015

Garcia Jennifer F, Al-Sady Bassem, Madhani Hiten D

Abstract excerpt

Effective boundary mechanisms halt the spread of repressive histone methylation. In the fission yeast Schizosacchromyces pombe, two factors/elements required for boundary function have been described, the jmjC protein Epe1 and binding sites for the RNA polymerase III transcription factor TFIIIC. Perplexingly, individual mutation of Epe1 or TFIIIC sites produces only mild boundary defects, and no other boundary...

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Share to Chromatin Immunoprecipitation
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterochromatin

Share to Histone-Lysine N-Methyltransferase

Share to Inverted Repeat Sequences

Share to Methyltransferases

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Share to Schizosaccharomyces pombe Proteins

Source

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Identifiers

PMID: 25957277
DOI: 10.1534/g3.115.018663
PMCID: PMC4502379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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