Article
A novel type of silencing factor, Clr2, is necessary for transcriptional silencing at various chromosomal locations in the fission yeast Schizosaccharomyces pombe.
Nucleic acids research - 1 Jan 2004
Bjerling Pernilla, Ekwall Karl, Egel Richard, Thon Geneviève
Abstract excerpt
The mating-type region of the fission yeast Schizosaccharomyces pombe comprises three loci: mat1, mat2-P and mat3-M. mat1 is expressed and determines the mating type of the cell. mat2-P and mat3-M are two storage cassettes located in a 17 kb heterochromatic region with features identical to those of mammalian heterochromatin. Mutations in the swi6+, clr1+, clr2+, clr3+, clr4+ and clr6+ genes were obtained in...
Topics
- Acetylation
- Chromosomes, Fungal
- Cloning, Molecular
- Gene Expression Regulation, Fungal
- Gene Silencing
- Genes, Fungal
- Genes, Mating Type, Fungal
- Histones
- Molecular Sequence Data
- Mutation