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Article

Establishment and maintenance of a heterochromatin domain.

Science (New York, N.Y.) - 27 Sept 2002

Hall Ira M, Shankaranarayana Gurumurthy D, Noma Ken-Ichi, Ayoub Nabieh, Cohen Amikam, Grewal Shiv I S

Abstract excerpt

The higher-order assembly of chromatin imposes structural organization on the genetic information of eukaryotes and is thought to be largely determined by posttranslational modification of histone tails. Here, we study a 20-kilobase silent domain at the mating-type region of fission yeast as a model for heterochromatin formation. We find that, although histone H3 methylated at lysine 9 (H3 Lys9) directly recruits...

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PMID: 12215653
DOI: 10.1126/science.1076466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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