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Article

A novel jmjC domain protein modulates heterochromatization in fission yeast.

Molecular and cellular biology - 1 Jun 2003

Ayoub Nabieh, Noma Ken-ichi, Isaac Sara, Kahan Tamar, Grewal Shiv I S, Cohen Amikam

Abstract excerpt

The heterochromatin domain at the mat locus of Schizosaccharomyces pombe is bounded by the IR-L and IR-R barriers. A genetic screen for mutations that promote silencing beyond IR-L revealed a novel gene named epe1, encoding a conserved nuclear protein with a jmjC domain. Disruption of epe1 promotes continuous spreading of heterochromatin-associated histone modifications and Swi6 binding to chromatin across...

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Identifiers

PMID: 12773576
DOI: 10.1128/MCB.23.12.4356-4370.2003
PMCID: PMC156127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel jmjC domain protein modulates heterochromatization in fission yeast.PMID 12773576Read ↗

Interaction of Epe1 with the heterochromatin assembly pathway in Schizosaccharomyces pombe.Semantic proximity Read ↗

The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.Semantic proximity Read ↗

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Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.Semantic proximity Read ↗

Analysis of a Rpb2 mutant in <i>Schizosaccharomyces pombe</i> reveals a non-canonical role for Elp1 in regulating RNAi-dependent heterochromatin assemblySemantic proximity Read ↗

Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.Semantic proximity Read ↗

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Establishment and maintenance of a heterochromatin domain.Semantic proximity Read ↗

Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast.Semantic proximity Read ↗

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