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Article

An enhancer screen identifies new suppressors of small-RNA-mediated epigenetic gene silencing.

PLoS genetics - 1 Jun 2021

Shimada Yukiko, Carl Sarah H, Skribbe Merle, Flury Valentin, Kuzdere Tahsin, Kempf Georg, Bühler Marc

Abstract excerpt

Small non-protein coding RNAs are involved in pathways that control the genome at the level of chromatin. In Schizosaccharomyces pombe, small interfering RNAs (siRNAs) are required for the faithful propagation of heterochromatin that is found at peri-centromeric repeats. In contrast to repetitive DNA, protein-coding genes are refractory to siRNA-mediated heterochromatin formation, unless siRNAs are expressed in...

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Identifiers

PMID: 34157021
DOI: 10.1371/journal.pgen.1009645
PMCID: PMC8253403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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