Article
The pathogenic APP N-terminal Val225Ala mutation alters tau protein liquid-liquid phase separation and exacerbates synaptic damage.
Molecular psychiatry - 1 Jun 2025
Chen Jiang, Li Song, Zhang Fengning, Chen Junsheng, Cai Chuanbin, Guo Yi, Lei Zhifeng, Zeng Ling-Hui, Zi Dan, Shen Yong, Tan Jun
Abstract excerpt
Amyloid precursor protein (APP) is predominantly located in synapses of neurons and its mutations have been well recognized as the most important genetic causal factor for the familial Alzheimer's disease (AD). While most disease-causal mutations of APP occur within the Aβ-coding region or immediately proximal, the pathological impacts of mutations in the N-terminus of APP protein, which remote from the Aβ...
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