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Article

The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation.

Progress in molecular biology and translational science - 1 Jan 2020

Webber Chelsea J, Lei Shuwen Eric, Wolozin Benjamin

Abstract excerpt

Liquid-liquid phase separation (LLPS) brings together functionally related proteins through the intrinsic biophysics of proteins in a process that is driven by reducing free energy and maximizing entropy. The process of LLPS allows proteins to form structures, termed membrane-less organelles. These diverse, dynamic organelles are active in a wide range of processes in the nucleus, cytoplasm, mitochondria and...

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Identifiers

PMID: 32828466
DOI: 10.1016/bs.pmbts.2020.04.021
PMCID: PMC8265525

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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