Tau dysfunction in alzheimer's disease: molecular and cellular mechanisms, genetic modulation, and therapeutic perspectives.

Abstract excerpt

Amyloid-beta (Aβ) plaque formation and tauopathy are two of several hallmarks of Alzheimer's disease (AD), a neurodegenerative disease. AD's widely known pathological hallmarks include extracellular amyloid-β deposition, neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein, synaptic dysfunction, neuroinflammation, and cognitive decline. These pathological hallmarks can be explained at the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloid beta-Peptides
• Share to Amyloid beta-Protein Precursor